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Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression

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SIRT2, the primary sirtuin localized in the cytoplasm, shows decreased expression during the transition from mitochondrial OXPHOS to glycolysis when cells transform into cancer cells

Lancet 321:13751376 Waring WS, Stephen AF, Malkowska AM, Robinson ODG (2008) Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose