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All participants received a treatment dosage once a week for 32 weeks

In contrast, M-CuP showed negligible binding to either target, with maximal responses below 5 response units (RU) across all tested concentrations, confirming the essential role of multivalent architecture in cooperative target engagement

The high activity of 30 prompted a synthesis of the corresponding disulfide 32 with a 14-membered ring system anticipated be able to adopt a similar trans conformation as 30

No genotoxicity, mutagenicity, or organ-specific toxicity was reported at the doses tested in the preclinical safety evaluation

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