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In addition, large organoids might cause more damage to recipients than small organoids if they are transplanted in deep areas of the brain

The research examined how different delivery systems (LNPs or polyplex nanomicelles) and administration routes (intramuscular or intravenous) of 5moU-modified FLuc mRNA affected reporter signaling, toxicity, muscle damage, and post-injection pain

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Which is why vials are shipped under vacuum or inert gas and must remain sealed until reconstitution

On the other hand, deubiquitinases (DUBs) remove ubiquitin chains from ubiquitinated proteins (Ronau et al., 2016)