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doi: 10.1021/jm300713s 148 LiaoWCHuangMZWangMLLinCJLuTLLoHRet al

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These models capture nonlinear interactions such as action potential generation and synaptic integration through differential equations representing ionic currents (e.g., I Na = g Na m^3 h (V-E Na ) for sodium currents) [65],[66], where: I is the sodium current, Na g is the maximal sodium conductance, Na m is the activation gating variable, h is the inactivation gating variable, V is the membrane potential, and where E is the sodium reversal potential