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Quercetin may also prevent AKI by regulating Mincle/Syk/NF-B signaling to inhibit macrophage inflammation (Tan et al., 2020)

As the disease progresses, persistent proinflammatory signaling promotes macrophage activation, foam cell formation, and fibrous cap destabilization

human Nrf2 lentiviral vector, LiCl

Screening, QTc changes, and increases above relevant thresholds are presented

90,91 Oxidative stress-induced inflammageing Based on the close relationships between oxidative stress, inflammation, and ageing, De La Fuente and Miquel proposed an oxidation-inflammatory theory of ageing (oxi-inflammageing)