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The histopathology of cirrhosis shows extensive necrosis of hepatocytes, nodular regeneration of residual hepatocytes, connective tissue hyperplasia, and fibrous septum formation, resulting in the destruction of the liver lobule structure and formation of pseudolobules ( The anti-inflammatory effect of caffeine varies with the treatment protocols and doses ( In the early stage of liver cirrhosis, there are no obvious symptoms due to the strong liver compensatory function, while in the later stage, liver function damage and portal hypertension are the main manifestations, and multiple systems are involved

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232,234 MSC therapy to promote healthy endometrial tissue has also been proposed as a future treatment for endometrial problems related to infertility, such as Asherman syndrome (intrauterine adhesions) and possibly even endometriosis

Direct administration on the formed fistula and initiation of the whole chain of events can be seen as a direct cytoprotective effect (note, a direct cytoprotective effect was noted also in vitro studies (136, 137))

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