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Thus, in the context of a cardiotoxin known to produce superoxide, excess GPx1 mitigated ROS-mediated cardiac damage

As an antioxidant enzyme, GPX4 may efficiently reduce lipid peroxidation (Ursini and Maiorino, 2020)

J Ethnopharmacol 156:1908 Sasaki T, Maruyama H, Kase Y, Takeda S, Aburada M (2005) Antianginal effects of lercanidipine on the vasopressin or methacholine induced anginal model in rats