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Kupffer cells may also be exposed to lower glutamine concentrations than observed in the plasma because their sinusoidal arrangement within the hepatic lobule does not allow all cells to come into direct contact with circulating blood

Furthermore, p53 has been reported to suppress mitophagy

Since cysteine is the least abundant amino acid, GGT and the gamma-glutamyl cycle are vital for GSH metabolism, especially during cysteine shortages 34 35 36

TABLE 2 Mechanisms and therapeutic advantages of nanocarriers delivering plant-derived secondary metabolites in myocardial ischemia-reperfusion injury

This is always a possibility with surgical procedures