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[15] [16] Measurement of blood level is important in assessing prognosis, higher levels predicting a worse prognosis

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As a GABA receptor antagonist, picrotoxin interacts with the GABA receptor to induce convulsions

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The GLU hypothesis of schizophrenia 4 grew out of the observation that phencyclidine, a drug of abuse that is a potent NMDA antagonist (50-fold stronger than ketamine), can trigger in healthy individuals a severe psychosis indistinguishable from schizophrenia, with positive and negative symptoms, cognitive impairment, thought disorder, catatonia, and agitation