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Polyphyllin I overcomes EMT-associated resistance to erlotinib in lung cancer cells via IL-6/STAT3 pathway inhibition

Erdemoglu AK, Varlibas A

[PMC free article: PMC4441672] [PubMed: 25666208] (23 year old man developed rash [photosensitive], fever and jaundice several months after starting Hydroxycut for weight loss [bilirubin 24.4 mg/dL, ALT 92 U/L, Alk P 91 U/L, INR 1.5] and had a prolonged and complicated course during which the diagnosis of hereditary coproporphyria was made, possibly explaining at least some of the clinical features)

In the case of lipid peroxides, Nrf2 has been known to upregulate the expression of AKR as a response to oxidative stress (13, 39)

Leavy OC, Ma SF, Molyneaux PL, Maher TM, Oldham JM, Flores C, et al