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Following OA induction, the rabbits were randomly divided into four groups with 8 subjects, each receiving a different weekly intra-articular treatment starting four weeks after the first collagenase injection

No controlled human trial has validated a topical AHK-Cu concentration or schedule

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In these scenarios, a higher-dose B12 supplement (typically 502,000 micrograms daily) or prescribed treatment may be necessary to restore and maintain adequate levels

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