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Thus, increasing age is the most important risk factor for nuclear cataract development, but a variety of other associations have been identified by epidemiologic studies

Some VLCDs, like Atkins diet, restrict carbohydrate intake to less than 20 g per day while allowing sufficient fat and protein consumption [327]

Mechanistically, mitochondrial delivery of Cu 2+ via ionophores (e.g., elesclomol) triggers FDX1-mediated reduction to Cu + , which induces proteotoxic stress through three convergent axes: ( + binding to TCA cycle components (e.g., DLAT)

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