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Posttranscriptional aspects of polyamine-mediated gene regulation are associated with the eukaryotic translation initiation factor 5A (eIF5A), whose expression/function is strongly correlated with unfavorable prognostic implications for several cancers 73,74,75

5.1 Passive targeting strategies Polymeric nanoscale carriers (10200 nm) passively accumulate in tumors via the enhanced permeability and retention (EPR) effect due to leaky vasculature and impaired lymphatic drainage