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The constructed carrier-free indocyanine green nanoparticles (NanoICG) have smaller and more uniform sizes and better fluorescent performance compared to ICG molecules, without any molecular structure changes, and have demonstrated excellent imaging performance and effects in liver cancer surgery fluorescence navigation and lymph node imaging recognition

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This action of CHAC1, known as the blocker of NOTCH, effectively reduces the cell surface expression of the full-length NOTCH1 receptor, thus inhibiting the NOTCH1 signaling pathway and contributing to the suppression of T-ALL cell viability (Chang Soo et al., 2023)