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To prevent medication overuse headache, migraine patients should (on average) limit use of NSAIDs to 15 or fewer days a month and limit triptan or over-the-counter combination analgesic use to 9 or fewer days a month (Garza 2012

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After 28 days at room temperature, you must refrigerate unused medication or discard it according to your pharmacy's guidelines

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So, it's important for the immune system, for nervous function, and cognitive function as well