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The chamber was preset to 10% CO 2 at 33 during the culture phase

(Lower temperature and lower IPTG concentration could reduce the formation of inclusion bodies and consequently increase the solubility of the synthesized protein)

The sensitization potential of CB-839 on cells treated with venetoclax ( Figures 6AC ), AZD-5991 ( Figures 6DF ), or ibrutinib ( Figures 6GI ) was assessed using the Loewe additivity model and validated using annexin V/PI staining