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FORMULATION HIGHLIGHTS

Gene expression analysis Total RNA was extracted from cells or tissues using Trizol (Thermo Fisher Scientific) or the RNeasy kit (QIAGEN)

JR: Methodology (supporting), Supervision (equal), Writing-reviewing and editing (equal), Resources (equal)

This can be summarized as follows: + Coenzyme A + + This enzyme is part of ethanol fermentation in certain species, and in particular the conversion of pyruvate to ethanol

51,52 Mtb infection activates both of these NLRs in an ESX-1-dependent manner to trigger various host downstream innate immune responses, such as NLRP3 inflammasome formation, autophagy initiation and NF-B and IRF3 pathway activation, which have been extensively reviewed elsewhere