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In September 2023, the FDA placed BPC-157 on the Category 2 Bulk Drug Substance list, citing significant safety concerns including immunogenicity and a lack of human clinical data [10]

The following serious adverse reactions are described elsewhere in the labeling: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

Liposomal oral formulations glutathione wrapped in a fat-soluble carrier improve absorption meaningfully, but they still do not approach the tissue concentrations IV delivery achieves

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Recently reported Mn-doped Prussian blue (PB-Mn/OVA NEs), Mn-doped polydopamine nanoparticles, and Au@MnO 2 nanoplatforms have all demonstrated outstanding photothermal performance (77, 107, 148)