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this normalized glutamate acts on presynaptic type 2/3 metabotropic glutamate receptors to moderate pathologically elevated synaptic glutamate release (Moran, McFarland, Melendez, Kalivas, & Seamans, 2005)

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The SAINT Neuromodulation System is a non-invasive repetitive transcranial magnetic stimulation (rTMS) system that identifies an individualized target and delivers navigationally directed repetitive magnetic pulses to that individualized target located within the left dorsolateral prefrontal cortex (L-DLPFC) to treat Major Depressive Disorder (MDD) in adult patients who have failed to achieve satisfactory improvement from prior antidepressant medication in the current episode

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