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Stewart Postharvest Rev

Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96

doi: 10.1016/j.bbi.2017.02.013 7 CervettoCVenturiniAPassalacquaMGuidolinDGenedaniSFuxeKet al

Rather than simply putting every patient on the same protocol, the better approach is first to determine whether you are an appropriate candidate for an aggressive calorie-restricted plan, whether you have underlying medical concerns, and whether a safer or more sustainable option may be better for you

There's definitely a strong genetic link