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Int J Mol Sci (2013) 13(11):1383066

(2) Between 4446 h later, animals were euthanased by cervical dislocation, and ovaries rapidly collected

found that CBP (cAMP-responsive element-binding (CREB)-binding protein) and SIRT4 in PDAC cells bind the K44 site of BCAT2 to acetylate this site, which further promotes the degradation of BCAT2 through the ubiquitin-protein pathway, reduces the metabolic rate of BCAAs in PDAC, and, in turn, inhibits the growth of tumor cells