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It is likely that circulating coenzyme Q 10 concentrations are decreased because statins reduce circulating lipids rather than because they inhibit coenzyme Q 10 synthesis (124)

Biochem Pharmacol 1998

We selected the G12D and G12V mutations because of their high frequency across all KRAS-driven cancers (including colorectal cancer) (Figure S1A), G12C for its high prevalence only in lung adenocarcinoma, and G12A because it is infrequently observed in colorectal adenocarcinoma yet biochemically indistinguishable from G12V 7