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Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function

However, the relevant mechanism of GPX3 kidney injury is still unclear

It is important for patients to maintain muscle function and effectively manage occurrences of contractures

Ethics declarations Competing interests The authors declare the following competing interests: T.M

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