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Moreover, this is further promulgated by the increased viscosity of blood due to the leakage of plasma and proteins from permeable blood vessels to the tumor interstitium, ultimately leading to hypoxia and acidosis in the TME [42,43]

Dynamics of newly-forming/formed OLs The differentiation of OPCs to generate new OLs and produce new myelin are essential processes for successful remyelination in human demyelinating diseases such as MS and in animal models of demyelination, although some recent studies have also argued for the contribution of pre-existing surviving mature Ols (Bacmeister et al., 2020

Renal dipeptidase has been mapped to human chromosome 16 at q24 [50]