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H2AX H2A histone family member X

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IGF1 has pleiotropic actions in the heart

Baker DG, Nievergelt CM, OConnor DT

Hence, not only there is the need of more basic research to understand the etiopathology of curcumin-related hepatotoxicity and of the combination curcumin-piperine, but human trials will be necessary to settle this dispute

Since the hallmark of SCD is chronic hemolysis with excess hemin producing significant levels of oxidative stress, we speculate that hemin may modulate TSS pathway function