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The MCHR1 antagonist GW-856464 also entered Phase I studies in 2004

a single dose methylcobalamin of 1500 mcg in patients with peripheral neuropathy

The patients without a history of gastrectomy complained of pain in other intraoral mucosal areas (5/11, 45.5 %), dry mouth (3/11, 27.3 %), and dysgeusia (2/11, 18.2 %)