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a multilayered approach that concurrently inhibits synovial inflammation, modulates immunometabolic processes, and safeguards chondrocytes from ferroptosis-induced injury may yield more robust clinical benefits

Timing Optional Marker Homocysteine Why it matters Adds methylation and cardiovascular context when B-vitamin status is being reviewed

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Once produced, TMA is absorbed into the bloodstream and transported to the liver, where it undergoes further oxidation to form TMAO via the enzyme FMO-3 [23, 25]