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We also used affinity purificationmass spectrometry (APMS) to map the interactions of CRBN globally 42 , which revealed an exquisitely selective and dHTC1-dependent enrichment of ENL, AF9 and other members of the super elongation complex (SEC) (Extended Data Fig

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We subsequently started the patient on oral antihistamine (diphenhydramine 25 mg every 6 hours), which relieved her symptoms at the time

This increase in mucus viscosity hinders the transport of mucus by cilia, causing a buildup of mucus in the airways, leading to breathing problems and an increase in susceptibility to infections (Auschwitz et al