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Its dense network of peripheral nerve endings provides the anatomical basis for localized neurotransmitter release and spatially restricted neuromodulation

Sirt3 is required for HSC self-renewal under stress conditions by suppressing reactive oxygen species (ROS) and ameliorating loss of HSC quiescence and death 30

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Iron staining Embedded tissues were frozen sectioned (7 m thick) and mounted on a poly-L-Lysine coated glass slides

However, we should consider that the long-lived organisms have evolved to adapt to high Nrf2 activity and fine-tuned complex systems of interactions of the signaling and metabolic pathways