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Although some irAEs are more common with CTLA-4 inhibitors than with PD-1 or PD-L1 inhibitors, pneumonitis is more common in patients treated with PD-1 inhibitors, such as nivolumab or pembrolizumab, though the mechanism for this difference is unclear

The potential of apigenin to combat a variety of cancers by initiating programmed cell death, inducing cell-cycle arrest, decreasing metastatic behavior, and preventing tumor vascularization is further demonstrated by experimental data from in vitro and in vivo investigations

Both choline and methionine are a source of methyl groups for the one-carbon transmethylation pathway and serve hepato-protective functions