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Both fluoxetine and norfluoxetine undergo conjugation with glucuronic acid in the liver, and limited evidence from animals suggests that both the parent drug and its principal metabolite also undergo O-dealkylation to form p-trifluoromethylphenol, which subsequently appears to be metabolized to hippuric acid

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Again, neither compound improved running distance nor ameliorated the postrun lactic acidosis (Figure 1, A and B)

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