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Research into peptide stability shows that factors like sequence, synthesis quality, and storage all interplay to set that expiration clock

Chem Soc Rev 46:40424076

[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration

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Scaling laboratory formulations into clinically viable products requires adherence to Good Manufacturing Practices (GMP) [119], with stringent demands for reproducibility, sterility, and batch-to-batch consistency