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Gwak et al., 2011)

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Finasteride is a synthetic 4-azasteroid compound whose antiandrogenic effect stems from its capacity to inhibit 5-alpha reductase, which is accountable for the conversion of testosterone to dihydrotestosterone (DHT)

Calculation of free energy of stabilization Assuming a two-state model of denaturation of the protein, the spectroscopic data was converted into the free energy of unfolding for each data point (G D )