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DAM release superoxide radicals (i.e., ROS), nitric oxides, and pro-inflammatory cytokines and factors (IL-1, TNF-, C1q), which induce neurotoxic C3 + reactive astrocytes (Liddelow et al., 2017)

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10.1038/s41397-024-00326-1 29 ChuA.WadhwaR

In recent years, polyphenolic compounds have become a research hotspot due to their anti-inflammatory, antioxidant, and microbial regulatory properties, demonstrating potential application value in the treatment of CD

In the 1970s there were a significant number of cases in the Royal Infirmary poisons unit in Edinburgh, and Laurie Prescott and colleagues did important work, allowing rapid progress in knowledge