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Unlike normal cells which rely on aerobic glucose metabolism, CLL cells depend on the aberrant lipid metabolism and mitochondrial OXPHOS to support survival and growth

Beste 1,3 and George Ioannou 1,2 , (1)University of Washington, (2)Veterans Affairs Puget Sound Healthcare System, (3)VA Puget Sound Healthcare System Background: Liver steatosis is common in patients with chronic liver disease (CLD), but whether the degree and etiology of steatosis predicts disease progression or mortality remains unknown

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Targeting ferroptosis using nanoparticles Compared to small-molecule compounds, ferroptosis-inducing nanoparticles have been suggested to have a better preclinical profile