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10.1016/j.engreg.2023.04.001 47 DzamkoN

Uzunova V, Sheline Y, Davis JM, Rasmusson A, Uzunov DP, Costa E, et al

Transgenic Res 18:787799

Oxidative stress induced in pathologies: The role of antioxidants

Collectively, our findings demonstrate that the GPX4 inhibition by RSL3 in PTC cells induces cell death, ferroptosis, lipid peroxidation, increased intracellular ROS burden, and significantly impairs thyroid tumor cell migration, 3D PTC spheroid fotmation and results in reduced spheroid viability in vitro