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Simultaneously, we further examined the transcriptomic data and found that, apart from the significant downregulation of several individual genes such as Jak2 and Il6ra, the JAKSTAT pathway was not significantly enriched at the transcriptional level

Activation of the TLR pathway is essential for the normal function of the immune system, but overactivation of this pathway has occurred in UC patients and UC animal models

Aug 25 2010;58(16):8977-8982

For mice receiving insulin supplementation, insulin pellets (LinBit, LinShin Canada) were also placed subcutaneously on the right flank at the time of surgery