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Notably, the deletion of Gclc in tumours did not affect their growth (Fig

Moossavi S, Besharat S, Sharafkhah M, et al

In acute situations, the critical loss of hepatocyte compromises liver functions and eventually leads to liver failure, and liver regeneration replenishes the lost hepatocytes to maintain liver functions

Conclusion: In congestive hepatopathy, mechano-stress in the liver sinusoids activates YAP/TAZ and enhances CTGF expression in LSECs, which may contribute to the development of liver fibrosis and portal hypertension