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Although the APAP toxicity-associated acute liver failure has better outcome than other causes of liver failure, mortality is still significant in 30% of cases without a liver transplant (for those who are deemed in need of a transplant)

Role of compartmentation in promoting toxicity of leukocyte-generated strong oxidants

We moved away from IV because intracellular NAD+ levels, which is where the benefit actually happens, do not reliably increase with IV administration

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