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27 While the true impact of CFTR modulators has not been evaluated, the Cystic Fibrosis Foundation (CFF) reports that more than 24,000 individuals with CF were taking a CFTR modulator by the end of 2022, with an estimated 72% taking ETI

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Further studies are necessary to clearly delineate the major NAD + biosynthetic pathways and NAD + consumption routes during macrophage phenotypic transition to determine whether the observed decline in NAD + levels depends on context and time and to determine the molecular mechanisms through which NAD + levels alter macrophage polarization states and functions

doi: 10.1007/s00203-022-02899-6, 4 AkmukhanovaN