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Subcutaneous administration of amifostine: a promising therapeutic option in patients with oxaliplatin-related peripheral sensitive neuropathy

Management requires immediate removal of the stimulus, most commonly a distended neurogenic bladder , and administration of rapid-acting antihypertensive agents if blood pressure remains dangerously elevated

A substantial proportion of these compounds are lipophilic in nature and exhibit extremely low solubility in the aqueous environment of the gastrointestinal tract