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The 2 individual patient-reported components (stool frequency and rectal bleeding) are part of the Mayo score and were not powered for statistical significance Correlation of depicted PROs to Week 6 and Week 52 primary end points was not evaluated in the analysis GEMINI I TRIAL EXPLORATORY END POINTS: PATIENT-REPORTED OUTCOMES Overall population compared with placebo Not powered for statistical significance

For each ligand and receptor, the table shows their spatial correlation, entropy (representing cell type specific expression), cell-type with maximal expression, and P and q values

Subsequently 10 M Cp1B, 2.5 mM l-isoleucine, 10 mM ATP, 10 mM MgCl 2 were added followed by incubation at 30 C for 16 h

Nucleotide specificity was assessed using the G3PDH-coupled assay, as described below, by substituting 5 mM GTP, CTP, or phosphoenolpyruvate (PEP) for ATP at 75 C

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