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Collectively, the above evidences suggest that PUFAs peroxidation is a vital prerequisite for ferroptosis

They play crucial and diverse roles in host physiology, including regulating the immune system, maintaining intestinal homeostasis, restoring the integrity of the intestinal barrier, facilitating intracellular signal transduction, and broadly influencing host metabolism

Sherman, W

Increased colonic epithelial permeability and mucosal eosinophilia in ulcerative colitis in remission compared with irritable Bowel syndrome and health

Piglet samples were obtained from sex-balanced cohorts to minimize the potential influence of sex