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10.1037/a0014260 258

Similarly, in D-galactose-induced aging rats, Astragalus polysaccharide modulates the PI3K/Akt and NAMPT/SIRT1 pathways, regulates the TERT/p53 axis, alleviates neuronal degeneration in hippocampal subregions, and reduces cerebral oxidative stress, thereby establishing a microenvironment conducive to BBB maintenance and cognitive enhancement (97)