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In diabetic retinopathy, PDGF-B is downregulated by two mechanisms: First, hyperglycemia reduces PDGF-B receptor tyrosine kinase activity, which induces pericyte apoptosis [16]

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Recent studies have also focused on the fine regulatory mechanisms of inflammatory response, such as the activation of NLRP3 inflammasome in sensing various danger signals (Seoane et al., 2020), and the complex role of Hypoxia-inducible factors (HIFs) in regulating inflammation and immune response (Foglia et al., 2021)

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