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But now it's exactly the reverse." Another possible target for modulating microglial activity is the complement system, a signaling pathway that can tag molecular danger signalsor mistakenly, synapsesfor microglia to consume

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Combination therapies, such as Miltefosine with Paromomycin or liposomal Amphotericin B, are also being investigated to improve effectiveness and reduce treatment duration ( Nanoparticle formulations of Amphotericin B, including topical options, are being trialed for safer, localized treatment of CL lesions ( 7 Emerging drug targets in Leishmania Recent advances in molecular and cellular biology have identified several promising drug targets that could pave the way for novel therapeutic interventions ( Leishmania parasites, suggesting its potential as a therapeutic target for visceral leishmaniasis (Wyllie et al., 2018)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Gonca E., Darici F