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Some mediators are relatively organ-enriched, whereas others (e.g., FGF21) are liver-dominant but not liver-exclusive

Mouse strains are described in the electronic supplementary material (ESM) Methods and were purchased from The Jackson Laboratory (Bar Harbor, USA) except for human islet amyloid polypeptide (hIAPP) knockin mice, which were developed previously [23] and provided by S

These include its abilities to fight oxidation, reduce inflammation, and kill harmful germs

Glutathione side effects are typically mild to negligible in most clinical studies, with nausea, abdominal discomfort, and allergic reactions reported in less than 5% of users

10.1038/ncb3064 advance online publication [DOI] [PMC free article] [PubMed] [Google Scholar] 8.Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, et al