Reprogramming of Treg cell-derived small extracellular vesicles effectively prevents intestinal inflammation from PANoptosis by blocking mitochondrial oxidative stress
Abbreviations 7nAChRs: Alpha-7-nicotinic acetylcholine receptors A: Amyloid- AD: Alzheimers disease ASD: Autism spectrum disorder ACh: Acetylcholine Akt: Protein kinase-B Bax: Bcl-2-associated X protein Bcl-2: B-cell lymphoma-2 CNS: Central nervous system DhE: Dihydro--erythroidine GABA: Gamma-aminobutyric acid GSH: Glutathione GPX: Glutathione peroxidase Hg: Mercury IL-1: Interleukin-1 MDA: Malondialdehyde MLA: Methyllycaconitine NF-B: Nuclear factor kappa B Nfr2: Nuclear factor erythroid 2related factor 2 NO: Nitric oxide NDDs: Neurodevelopmental disorders NMDA: N -methyl-D-aspartate PI3K: Phosphoinositide 3-kinases PV: Parvalbumin ROS: Reactive oxygen species TNF-: Tumor necrosis factor-alpha WHO: World Health Organization References Hodges H, Fealko C, Soares N (2019) Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation
F., Guthmiller, J
It is known that BAs may regulate multiple physiological and pathological processes, implicating a role in the progression of NAFLD/NASH ( Bacteroides and Clostridium , which produced DCA accumulation in the feces, serum, and liver, and hepatic DCA led to sucralose-induced NAFLD in mice ( Accumulating studies have demonstrated that amino acids might play a role in the process of NAFLD/NASH, but the relationship hasnt been elucidated
Samples were agitated via vortex at 4 C for 30 min then centrifuged at 18,213 g for 10 min at 4 C
