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For example, second and third generation anaplastic lymphoma kinase inhibitors, brigatinib and lorlatinib, respectively, have also been unsuccessful in the treatment of primary brain tumors, despite achieving intracranial responses in the treatment of metastatic non-small cell lung cancer (124)

A major variability in the gut microbiota composition has also been reported, together with a lower abundance of Subdoligranulum species, the clinical relevance of which is under investigation [93]

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2026 Mar 12;45(3):117099