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In the absence of appropriate treatment, children with NASH are at risk for developing cirrhosis and dying from liver-related causes in their early adultery (Marshall et al., 2022)

In Europe, the European Medicines Agency supports two main regulatory tracks: well-established use and traditional use registration under Directive 2004/24/EC, which requires data on safety, efficacy, and pharmacovigilance

Disclosures: Het Patel: Nothing to Disclose, Nisha Sanghani: Nothing to Disclose, Ibrahim Ragab: Nothing to Disclose, Hammad Liaquat: Nothing to Disclose 2231 EXPLORING THE IMPACT OF LEAKY GUT SYNDROME MARKER SCD14 ON TREATMENT OUTCOMES IN LIVER CIRRHOSIS WITH WATER RETENTION Masato Nakai 1 Takashi Kitagataya 1 Masatsugu Ohara 1 Takuya Sho 1 Goki Suda 2 Naoya Sakamoto 2 , 1 Hokkaido University Hospital, 2 Graduate School of Medicine Hokkaido University Background: Elevated inflammatory markers have been reported as ineffective factors of Tolvaptan (TVP) for water retention associated with portal hypertension

CPB2, a key regulator of fibrinolysis, has previously been associated with thrombotic complications and disease severity in COVID-19 53,54,55

On the other hand, some studies show that saponin components play protective roles in alleviating kidney injury by regulating the NF-B signaling pathway to reduce inflammation